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CORUM: The comprehensive resource of mammalian protein complexes.

Nucleic Acids Res. 36, D646-D650 (2008)
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Open Access Gold
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Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. The CORUM (http://mips.gsf.de/genre/proj/corum/index.html) database is a collection of experimentally verified mammalian protein complexes. Information is manually derived by critical reading of the scientific literature from expert annotators. Information about protein complexes includes protein complex names, subunits, literature references as well as the function of the complexes. For functional annotation, we use the FunCat catalogue that enables to organize the protein complex space into biologically meaningful subsets. The database contains more than 1750 protein complexes that are built from 2400 different genes, thus representing 12% of the protein-coding genes in human. A web-based system is available to query, view and download the data. CORUM provides a comprehensive dataset of protein complexes for discoveries in systems biology, analyses of protein networks and protein complex-associated diseases. Comparable to the MIPS reference dataset of protein complexes from yeast, CORUM intends to serve as a reference for mammalian protein complexes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords FUNCTIONAL ANNOTATION; GENOME DATABASE; WHOLE GENOMES; YEAST; CELL; MODULARITY; NETWORK; MIPS
ISSN (print) / ISBN 0305-1048
e-ISSN 1362-4962
Quellenangaben Volume: 36, Issue: SI, Pages: D646-D650 Article Number: , Supplement: ,
Publisher Oxford University Press
Reviewing status Peer reviewed