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Couto Alves, A.* ; De Silva, N.M.G.* ; Karhunen, V.* ; Sovio, U.* ; Das, S.* ; Rob Taal, H.* ; Warrington, N.M.* ; Lewin, A.M.* ; Kaakinen, M.* ; Cousminer, D.L.* ; Thiering, E. ; Timpson, N.J.* ; Bond, T.A.* ; Lowry, E.* ; Brown, C.D.* ; Lindi, V.* ; Bradfield, J.P.* ; Geller, F.* ; Speed, D.* ; Coin, L.J.M.* ; Loh, M.* ; Barton, S.J.* ; Beilin, L.J.* ; Bisgaard, H.* ; Bønnelykke, K.* ; Alili, R.* ; Hatoum, I.J.* ; Schramm, K. ; Cartwright, R.* ; Charles, M.A.* ; Salerno, V.* ; Clément, K.* ; Claringbould, A.A.J.* ; van Duijn, C.M.* ; Moltchanova, E.* ; Eriksson, J.G.* ; Elks, C.* ; Feenstra, B.* ; Flexeder, C. ; Franks, S.* ; Frayling, T.M.* ; Freathy, R.M.* ; Elliott, P.* ; Widén, E.* ; Hakonarson, H.* ; Hattersley, A.T.* ; Rodriguez, A.* ; Banterle, M.* ; Heinrich, J. ; Heude, B.* ; Holloway, J.W.* ; Hofman, A.* ; Hyppönen, E.* ; Inskip, H.* ; Kaplan, L.M.* ; Hedman, A.K.* ; Läärä, E.* ; Prokisch, H. ; Grallert, H. ; Lakka, T.A.* ; Lawlor, D.A.* ; Melbye, M.* ; Ahluwalia, T.S.* ; Marinelli, M.* ; Millwood, I.Y.* ; Palmer, L.J.* ; Pennell, C.E.* ; Perry, J.R.* ; Ring, S.M.* ; Savolainen, M.J.* ; Rivadeneira, F.* ; Standl, M. ; Sunyer, J.* ; Tiesler, C.M. ; Uitterlinden, A.G.* ; Schierding, W.* ; Sullivan, O.M.* ; Prokopenko, I.* ; Herzig, K.H.* ; Smith, G.D.* ; O'Reilly, P.* ; Felix, J.F.* ; Buxton, J.L.* ; Blakemore, A.I.F.* ; Ong, K.K.* ; Jaddoe, V.W.V.* ; Grant, S.F.A.* ; Sebert, S.* ; McCarthy, M.I.*

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.

Sci. Adv. 5:eaaw3095 (2019)
Publ. Version/Full Text Postprint DOI
Open Access Gold
Creative Commons Lizenzvertrag
Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Body-mass Index; Genome-wide Association; Blood-pressure; Early-life; Metabolic Risk; Birth Cohort; Fto Gene; Adiposity; Obesity; Age
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Quellenangaben Volume: 5, Issue: 9, Pages: , Article Number: eaaw3095 Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place Washington, DC [u.a.]
Reviewing status Peer reviewed