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Kieback, A.G.* ; Espinola-Klein, C.* ; Lamina, C.* ; Moebus, S.* ; Tiller, D.* ; Lorbeer, R.* ; Schulz, A.* ; Meisinger, C. ; Medenwald, D.* ; Erbel, R.* ; Kluttig, A.* ; Wild, P.S.* ; Kronenberg, F.* ; Kröger, K.* ; Ittermann, T.* ; Dörr, M.*

One simple claudication question as first step in Peripheral Arterial Disease (PAD) screening: A meta-analysis of the association with reduced Ankle Brachial Index (ABI) in 27,945 subjects.

PLoS ONE 14:e0224608 (2019)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
Purpose and methodsA meta-analysis using data from seven German population-based cohorts was performed by the German Epidemiological consortium of Peripheral Arterial Disease (GEPArD) to investigate whether one question about claudication is more efficient for PAD screening than established questionnaires. Claudication was defined on the basis of the answer to one question asking for pain in the leg during normal walking. This simple question was compared with established questionnaires, including the Edinburgh questionnaire. The associations of claudication with continuous ABI values and decreased ABI were analyzed by linear and logistic regression analysis, respectively. The results of the studies were pooled in a random effect meta-analysis, which included data from 27,945 individuals (14,052 women, age range 20-84 years).ResultsMeta-analysis revealed a significant negative association between claudication and ABI, which was stronger in men (beta = -0.07; 95%CI -0.10, -0.04) than in women (beta = -0.02; 95%CI -0.02, -0.01). Likewise, the presence of claudication symptoms was related to an increased odds of a decreased ABI in both men (Odds ratio = 5.40; 95%CI 4.20, 6.96) and women (Odds ratio = 1.99; 95%CI 1.58, 2.51).ConclusionsAsking only one question about claudication was able to identify many individuals with a high likelihood of a reduced ABI with markedly higher sensitivity and only slightly reduced specificity compared to more complex questionnaires. At least in men, this question should be established as first screening step.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Intermittent Claudication; Risk-factors; Atherosclerotic Disease; Angina-pectoris; Sex-differences; Mortality; Prevalence; Health; Diagnosis; Profile
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 14, Heft: 11, Seiten: , Artikelnummer: e0224608 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Begutachtungsstatus Peer reviewed