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Expression and phase separation potential of heterochromatin proteins during early mouse development.

EMBO Rep. 20:e47952 (2019)
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Open Access Gold (Paid Option)
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In most eukaryotes, constitutive heterochromatin is associated with H3K9me3 and HP1 alpha. The latter has been shown to play a role in heterochromatin formation through liquid-liquid phase separation. However, many other proteins are known to regulate and/or interact with constitutive heterochromatic regions in several species. We postulate that some of these heterochromatic proteins may play a role in the regulation of heterochromatin formation by liquid-liquid phase separation. Indeed, an analysis of the constitutive heterochromatin proteome shows that proteins associated with constitutive heterochromatin are significantly more disordered than a random set or a full nucleome set of proteins. Interestingly, their expression begins low and increases during preimplantation development. These observations suggest that the preimplantation embryo is a useful model to address the potential role for phase separation in heterochromatin formation, anticipating exciting research in the years to come.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Development ; Epigenetics ; Heterochromatin Establishment ; Phase Separation; Histone H3; Complex Coacervation; Chromatin-structure; Rna-binding; Lysine 9; Liquid; Sequence; Domains; Methylation; Hp1-alpha
ISSN (print) / ISBN 1469-221X
e-ISSN 1469-3178
Journal EMBO Reports
Quellenangaben Volume: 20, Issue: 12, Pages: , Article Number: e47952 Supplement: ,
Publisher EMBO Press
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed