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Kundrát, P. ; Simonetto, C. ; Eidemüller, M. ; Remmele, J.* ; Rennau, H.* ; Sebb, S.* ; Wolf, U.* ; Hildebrandt, G.*

What anatomic features govern personal long-term health risks from breast cancer radiotherapy?

Radiat. Prot. Dosim. 186, 381-385 (2019)
Verlagsversion DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Breast cancer radiotherapy may in the long term lead to radiation-induced secondary cancer or heart disease. These health risks hugely vary among patients, partially due to anatomy-driven differences in doses deposited to the heart, ipsilateral lung and contralateral breast. We identify four anatomic features that largely cover these dosimetric variations to enable personalized risk estimates. For three exemplary, very different risk scenarios, the given parameter set reproduces 63-74% of the individual risk variability for left-sided breast cancer patients. These anatomic features will be used in the PASSOS software to support decision processes in breast-cancer therapy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Heart-disease; Radiation
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Quellenangaben Band: 186, Heft: 2-3, Seiten: 381-385 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed