PuSH - Publication Server of Helmholtz Zentrum München

Ricci, W.A.* ; Lu, Z.* ; Ji, L.* ; Marand, A.P.* ; Ethridge, C.L.* ; Murphy, N.G.* ; Noshay, J.M.* ; Galli, M.* ; Mejía-Guerra, M.K.* ; Colomé-Tatché, M. ; Johannes, F.* ; Rowley, M.J.* ; Corces, V.G.* ; Zhai, J.* ; Scanlon, M.J.* ; Buckler, E.S.* ; Gallavotti, A.* ; Springer, N.M.* ; Schmitz, R.J.* ; Zhang, X.*

Widespread long-range cis-regulatory elements in the maize genome.

Nat. Plants 5, 1237-1249 (2019)
Postprint DOI
Open Access Green
Genetic mapping studies on crops suggest that agronomic traits can be controlled by gene–distal intergenic loci. Despite the biological importance and the potential agronomic utility of these loci, they remain virtually uncharacterized in all crop species to date. Here, we provide genetic, epigenomic and functional molecular evidence to support the widespread existence of gene–distal (hereafter, distal) loci that act as long-range transcriptional cis-regulatory elements (CREs) in the maize genome. Such loci are enriched for euchromatic features that suggest their regulatory functions. Chromatin loops link together putative CREs with genes and recapitulate genetic interactions. Putative CREs also display elevated transcriptional enhancer activities, as measured by self-transcribing active regulatory region sequencing. These results provide functional support for the widespread existence of CREs that act over large genomic distances to control gene expression.
Additional Metrics?
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 2055-026X
e-ISSN 2055-0278
Journal Nature Plants
Quellenangaben Volume: 5, Issue: 12, Pages: 1237-1249 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed