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Fold designability, distribution and disease.

PLoS Comput. Biol. 2, 392-402:e40 (2006)
Publishers Version DOI PMC
Open Access Gold
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Fold designability has been estimated by the number of families contained in that fold. Here, we show that among orthologous proteins, sequence divergence is higher for folds with greater numbers of families. Folds with greater numbers of families also tend to have families that appear more often in the proteome and greater promiscuity ( the number of unique "partner'' folds that the fold is found with within the same protein). We also find that many diseaserelated proteins have folds with relatively few families. In particular, a number of these proteins are associated with diseases occurring at high frequency. These results suggest that family counts reflect how certain structures are distributed in nature and is an important characteristic associated with many human diseases.
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Publication type Article: Journal article
Document type Scientific Article
Keywords HUMAN GENETIC-DISEASE; PRIMATE COLOR-VISION; PROTEIN EVOLUTION; HUMAN GENOME; NATURAL-SELECTION; MOLECULAR-BASIS; SEQUENCE SPACE; DATABASE; RECOMBINATION; MUTATIONS
Reviewing status