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Mathematical modeling of variability in intracellular signaling.

Curr. Opin. Syst. Biol. 16, 17-24 (2019)
Postprint DOI
Open Access Green
Cellular signaling is essential in information processing and decision-making. Therefore, a variety of experimental approaches have been developed to study signaling on bulk and single-cell level. Single-cell measurements of signaling molecules demonstrated a substantial cell-to-cell variability, raising questions about its causes and mechanisms and about how cell populations cope with or exploit cellular heterogeneity. To gain insights from single-cell signaling data, analysis and modeling approaches have been introduced. This review discusses these modeling approaches, with a focus on recent advances in the development and calibration of mechanistic models. Additionally, it outlines current and future challenges.
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Publication type Article: Journal article
Document type Review
Keywords Heterogeneity ; Mechanistic Modeling ; Ordinary Differential Equation Models ; Single-cell Data
ISSN (print) / ISBN 2452-3100
e-ISSN 2452-3100
Quellenangaben Volume: 16, Issue: , Pages: 17-24 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Reviewing status Peer reviewed