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Marschall, M.* ; Strojan, H.* ; Kiener, R.* ; Wangen, C.* ; Sonntag, E.* ; Müller, R.* ; Zeitträger, I.* ; Wagner, S.* ; Stamminger, T.* ; Milbradt, J.* ; Behrends, U. ; Körber, N. ; Bauer, T. ; Schrödel, S.* ; Thirion, C.* ; Wagner, R.* ; Hutterer, C.*

Differential upregulation of host cell protein kinases by the replication of α-, β- and γ-Herpesviruses provides a signature o virus-specific signalling.

J. Gen. Virol. 101, 284-289 (2020)
Publ. Version/Full Text DOI
Infections with human herpesviruses share several molecular characteristics, but the diversified medical outcomes are distinct to viral subfamilies and species. Notably, both clinical and molecular correlates of infection are a challenging field and distinct patterns of virus-host interaction have rarely been defined: this study therefore focuses on the search for virus-specific molecular indicators. As previous studies have demonstrated the impact of herpesvirus infections on changes in host signalling path- ways, we illustrate virus-modulated expression levels of individual cellular protein kinases. Current data reveal (i) alpha- and beta-, gamma-herpesvirus-specific patterns of kinase modulation as well as (ii) differential levels of up-/downregulated kinase expression and phosphorylation, which collectively suggest (iii) defined signalling patterns specific for the various viruses (VSS) that may prove useful for defining molecular indicators. Combined, the study confirms the correlation between herpesviral replication and modulation of signalling kinases, possibly exploitable for the in vitro characterization of viral infections.
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Publication type Article: Journal article
Document type Review
Keywords Herpesviral Replication ; Primary Human Fibroblasts ; Modulation Of The Host Kinome ; Differential Upregulation Of Cellular Kinases ; Signature Of Virus-specific Signalling; Cytomegalovirus; Pul97; Pathogenesis; Kinome; Pul69; Pp65
ISSN (print) / ISBN 0022-1317
e-ISSN 1465-2099
Quellenangaben Volume: 101, Issue: 3, Pages: 284-289 Article Number: , Supplement: ,
Publisher Society for General Microbiology
Publishing Place Charles Darwin House, 12 Roger St, London Wc1n 2ju, Erks, England
Reviewing status Peer reviewed