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Scars or regeneration?-Dermal fibroblasts as drivers of diverse skin in wound responses.

Int. J. Mol. Sci. 21:617 (2020)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
Scarring and regeneration are two physiologically opposite endpoints to skin injuries, with mammals, including humans, typically healing wounds with fibrotic scars. We aim to provide an updated review on fibroblast heterogeneity as determinants of the scarring-regeneration continuum. We discuss fibroblast-centric mechanisms that dictate scarring-regeneration continua with a focus on intercellular and cell-matrix adhesion. Improved understanding of fibroblast lineage-specific mechanisms and how they determine scar severity will ultimately allow for the development of antiscarring therapies and the promotion of tissue regeneration.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Scarring ; Fibrosis ; Fibroblasts ; Regeneration ; Adhesion; Hair Follicle Regeneration; Growth-factor Receptor; Tissue Regeneration; Granulation-tissue; Hypertrophic Scars; Hippo Pathway; Factor-beta; Fibrosis; Cells; Expression
ISSN (print) / ISBN 1422-0067
e-ISSN 1661-6596
Quellenangaben Band: 21, Heft: 2, Seiten: , Artikelnummer: 617 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed