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Marouli, E.* ; Kanoni, S.* ; Mamakou, V.* ; Hackinger, S.* ; Southam, L.* ; Prins, B.* ; Rentari, A.* ; Dimitriou, M.* ; Zengini, E.* ; Gonidakis, F.* ; Kolovou, G.* ; Kontaxakis, V.* ; Rallidis, L.* ; Tentolouris, N.* ; Thanopoulou, A.* ; Lamnissou, K.* ; Dedoussis, G.* ; Zeggini, E. ; Deloukas, P.*

Evaluating the glucose raising effect of established loci via a genetic risk score.

PLoS ONE 12:e0186669 (2017)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
Recent genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) associated with glucose levels. We tested the hypothesis here whether the cumulative effect of glucose raising SNPs, assessed via a score, is associated with glucose levels. A total of 1,434 participants of Greek descent from the THISEAS study and 1,160 participants form the GOMAP study were included in this analysis. We developed a genetic risk score (GRS), based on the known glucose-raising loci, in order to investigate the cumulative effect of known glucose loci on glucose levels. In the THISEAS study, the GRS score was significantly associated with increased glucose levels (mmol/L) (β ± SE: 0.024 ± 0.004, P = 8.27e-07). The effect of the genetic risk score was also significant in the GOMAP study (β ± SE: 0.011 ± 0.005, P = 0.031). In the meta-analysis of the two studies both scores were significantly associated with higher glucose levels GRS: β ± SE: 0.019 ± 0.003, P = 1.41e-09. Also, variants at the SLC30A8, PROX1, MTNR1B, ADRA2A, G6PC2, LPIN3 loci indicated nominal evidence for association with glucose levels (p < 0.05). We replicate associations of the established glucose raising variants in the Greek population and confirm directional consistency of effects (binomial sign test p = 6.96e-05). We also demonstrate that the cumulative effect of the established glucose loci yielded a significant association with increasing glucose levels.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 12, Heft: 11, Seiten: , Artikelnummer: e0186669 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Translational Genomics (ITG)