as soon as is submitted to ZB.
Rate, spectrum, and evolutionary dynamics of spontaneous epimutations.
Proc. Natl. Acad. Sci. U.S.A. 112, 6676-6681 (2015)
Stochastic changes in cytosine methylation are a source of heritable epigenetic and phenotypic diversity in plants. Using the model plant Arabidopsis thaliana, we derive robust estimates of the rate at which methylation is spontaneously gained (forward epimutation) or lost (backward epimutation) at individual cytosines and construct a comprehensive picture of the epimutation landscape in this species. We demonstrate that the dynamic interplay between forward and backward epimutations is modulated by genomic context and show that subtle contextual differences have profoundly shaped patterns of methylation diversity in A. thaliana natural populations over evolutionary timescales. Theoretical arguments indicate that the epimutation rates reported here are high enough to rapidly uncouple genetic from epigenetic variation, but low enough for new epialleles to sustain long-term selection responses. Our results provide new insights into methylome evolution and its population-level consequences.
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Keywords Arabidopsis ; Dna Methylation ; Epigenetics ; Epimutation ; Evolution
ISSN (print) / ISBN 0027-8424
Quellenangaben Volume: 112, Issue: 21, Pages: 6676-6681
Publisher National Academy of Sciences
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)