Spatial entropy redistribution plays a key role in adiabatic cooling of ultra-cold lattice gases. We show that high-spin fermions with a spatially variable quadratic Zeeman coupling may allow for the creation of an inner spin-1/2 core surrounded by high-spin wings. The latter are always more entropic than the core at high temperatures and, remarkably, at all temperatures in the presence of frustration. Combining thermodynamic Bethe Ansatz with local density approximation, we study the spatial entropy distribution for the particular case of one-dimensional spin-3/2 lattice fermions in the Mott phase. Interestingly, this spatially dependent entropy opens a possible path for an adiabatic cooling technique that, in contrast to previous proposals, would specifically target the spin degree of freedom. We discuss a possible realization of this adiabatic cooling, which may allow for a highly efficient entropy decrease in the spin-1/2 core and help access antiferromagnetic order in experiments on ultracold spinor fermions.