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Introduction to epigenetic inheritance: Definition, mechanisms, implications and relevance.

In: Beyond Our Genes. 2020. 159-173
DOI

Complex phenotypes result from the interaction between genetic and environmental informations. Almost a decade ago, the discovery of acquired epigenetic inheritance has shown that individual’s environmental experiences can influence developmental and phenotypic trajectories across several generations. The field is now starting to unveil the molecular mechanisms, while its relevance for complex disease risk and adaptive evolution is still unclear and strongly debated. The aim of this chapter is to introduce the reader to the concept of epigenetic inheritance, provide an overview on the underlying molecular determinants and highlight its potential relevance for individual’s susceptibility to complex, non-mendelian, diseases.

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Publication type Article: Edited volume or book chapter
Keywords Complex Disease ; Disease Risk ; Dna Methylation ; Dohad ; Epigenetics ; Gene/environment Interaction ; Genetics ; Histone Post-translational Modification ; Non-coding Rnas ; Phenotypic Adaptation
Book Volume Title Beyond Our Genes
Quellenangaben Volume: , Issue: , Pages: 159-173 Article Number: , Supplement: ,