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Platts-Mills, T.A.E.* ; Commins, S.P.* ; Biedermann, T. ; van Hage, M.* ; Levin, M.* ; Beck, L.A.* ; Diuk-Wasser, M.* ; Jappe, U.* ; Apostolovic, D.* ; Minnicozzi, M.* ; Plaut, M.* ; Wilson, J.M.*

On the cause and consequences of IgE to galactose-α-1,3-galactose: A report from the National Institute of Allergy and Infectious Diseases Workshop on Understanding IgE-Mediated Mammalian Meat Allergy.

J. Allergy Clin. Immunol. 145, 1061-1071 (2020)
DOI Verlagsversion bestellen
Free by publisher: Verlagsversion online verfügbar 04/2023
The mammalian meat allergy known as the "alpha-Gal syndrome'' relates to IgE specific for galactose-alpha-1,3-galactose (alpha-Gal), an oligosaccharide that is present in cells and tissues of nonprimate mammals. The recognition of delayed reactions to food derived from mammals in patients with IgE to alpha-Gal and also the association with tick bites have been increasing worldwide. In 2018, the National Institute of Allergy and Infectious Diseases, Division of Allergy, Immunology and Transplantation, sponsored a workshop on this emerging tick-related disease. International experts from the fields of tick biology, allergy, immunology, infectious disease, and dermatology discussed the current state of our understanding of this emerging medical condition. The participants provided suggestions for specific research priorities and for the development of resources to advance our knowledge of the mechanisms, diagnosis, management, and prevention of this allergic disease. This publication is a summary of the workshop and the panel's recommendations are presented herein.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Alpha-gal ; Anaphylaxis ; Ige ; Oligosaccharide Allergen ; Glycolipids ; Mammalian Meat Allergy ; Ticks; Lone Star Tick; Forest Service Employees; Alpha-gal Allergy; Amblyomma-americanum; Anti-gal; Monoclonal-antibody; Structural-characterization; Natural Antibodies; I Sensitization; T-cells
ISSN (print) / ISBN 0091-6749
e-ISSN 1097-6825
Quellenangaben Band: 145, Heft: 4, Seiten: 1061-1071 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Begutachtungsstatus Peer reviewed