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Large animal models of diabetes.
In: Animal Models of Diabetes. Berlin [u.a.]: Springer, 2020. 115-134 (Methods Mol. Biol. ; 2128)
Safe and reliable large animal diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents but is often critiqued in higher animals due to reduced efficacy, relevant side effects, and inadequate mortality rate. In this chapter, we aim to describe both pharmacological and surgical approaches for reproducible and safe diabetes models in minipigs and primates. In addition, genetically modified pig models for diabetes research are described.
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Publication type Article: Edited volume or book chapter
Keywords Diabetes Induction ; Diabetes Model ; Pancreatectomy ; Pig Model ; Primate Model ; Streptozotocin
ISSN (print) / ISBN 1064-3745
Book Volume Title Animal Models of Diabetes
Journal Methods in Molecular Biology
Quellenangaben Volume: 2128, Pages: 115-134
Publishing Place Berlin [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)