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In vivo optoacoustic monitoring of percutaneous laser ablation of tumors in a murine breast cancer model.
Opt. Lett. 45, 2006-2009 (2020)
Laser ablation (LA) is a promising approach for minimally invasive cancer treatments. Its in vivo applicability is often impeded by the lack of efficient monitoring tools that can help to minimize collateral tissue damage and aid in determining the optimal treatment end-points. We have devised a new, to the best of our knowledge, hybrid LA approach combining simultaneous volumetric optoacoustic (OA) imaging to monitor the lesion progression accurately in real time and 3D. Time-lapse imaging of laser ablation of solid tumors was performed in a murine breast cancer model in vivo by irradiation of subcutaneous tumors with a 100 mJ short-pulsed (similar to 5 ns) laser operating at 1064 nm and 100 Hz pulse repetition frequency. Local changes in the OA signal intensity ascribed to structural alterations in the tumor vasculature were clearly observed, while the OA volumetric projections recorded in vivo appeared to correlate with cross sections of the excised tumors.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Real-time; Catheter; Therapy
ISSN (print) / ISBN 0146-9592
Zeitschrift Optics Letters
Quellenangaben Band: 45, Heft: 7, Seiten: 2006-2009
Verlag Optical Society of America (OSA)
Verlagsort 2010 Massachusetts Ave Nw, Washington, Dc 20036 Usa
Begutachtungsstatus Peer reviewed