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NNT in NSCLC: No need to worry?

J. Exp. Med. 217:e20200310 (2020)
Verlagsversion DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
In this study, Ward et al. (https://doi.org/10.1084/jem.20191689) provide exciting evidence that nucleotide nicotinamide transhydrogenase (NNT), a mitochondrial matrix-located enzyme harnessing the proton gradient to generate NADPH using NADH, markedly contributes to non-small cell lung carcinoma (NSCLC), which is abrogated in the murine C57BL/6J background, a strain known to be deficient in NNT.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Editorial
Schlagwörter Thioredoxin Reductase; Embryogenesis
ISSN (print) / ISBN 0022-1007
e-ISSN 1540-9538
Quellenangaben Band: 217, Heft: 6, Seiten: , Artikelnummer: e20200310 Supplement: ,
Verlag Rockefeller University Press
Verlagsort 950 Third Ave, 2nd Flr, New York, Ny 10022 Usa
Begutachtungsstatus Peer reviewed