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Coux, O.* ; Zieba, B.A.* ; Meiners, S.

The proteasome system in health and disease.

In: Proteostasis and Disease. New York: Springer, 2020. 55-100 (Adv. Exp. Med. Biol. ; 1233)
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The proteasome is involved in the regulation of all cellular pathways and consequently plays a central role in the control of cellular homeostasis. Together with its regulators, it is at the frontline, both as an actor and as a target, in human health and when homeostasis is disturbed in disease. In this review, we aim to provide an overview of the many levels at which the functions of the proteasome and its regulators can be regulated to cope with cellular needs or are altered in pathological conditions.
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Publikationstyp Artikel: Sammelbandbeitrag/Buchkapitel
Schlagwörter 19s Complex ; Disease ; Pa200 ; Pa28 ; Pi31 ; Proteasome; Activator Reg-gamma; Multicatalytic Proteinase Complex; Endoplasmic-reticulum Stress; 26 S-proteasome; 20s Proteasome; Oxidative-stress; Cell-cycle; Nuclear Proteasome; Interferon-gamma; Cigarette-smoke
ISSN (print) / ISBN 0065-2598
Bandtitel Proteostasis and Disease
Zeitschrift Advances in Experimental Medicine and Biology
Quellenangaben Band: 1233, Heft: , Seiten: 55-100 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort New York