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Pharmacological targeting of the actin cytoskeleton to drive endocrinogenesis.

Trends Pharmacol. Sci. 41, 384-386 (2020)
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In vitro generation of insulin-secreting beta cells from human pluripotent stem cells (hPSCs) opens new avenues for treating and modeling diabetes. Hogrebe and colleagues established a new 2D differentiation protocol where they targeted the cytoskeleton pharmacologically for controlled endocrine induction and generation of hPSC-derived beta cells with improved function.
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Publication type Article: Journal article
Document type Other: Opinion
Keywords Actin ; Beta Cells ; Endocrine Progenitors ; Latrunculin A ; Pancreatic Progenitors ; Stem Cells; Beta-cells; In-vitro
ISSN (print) / ISBN 0165-6147
e-ISSN 1873-3735
Quellenangaben Volume: 41, Issue: 6, Pages: 384-386 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Amsterdam
Reviewing status Peer reviewed