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Sungnak, W.* ; Huang, N.* ; Bécavin, C.* ; Berg, M.* ; Queen, R.* ; Litvinukova, M.* ; Talavera-López, C.* ; Maatz, H.* ; Reichart, D.* ; Sampaziotis, F.* ; Worlock, K.B.* ; Yoshida, M.* ; Barnes, J.L.* ; HCA Lung Biological Network (Schiller, H. B.)

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.

Nat. Med., accepted (2020)
Verlagsversion Forschungsdaten DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 1078-8956
e-ISSN 1546-170X
Zeitschrift Nature medicine
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus