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Dirven, L.* ; Luerding, R.* ; Beier, D.* ; Bumes, E.* ; Reinert, C.* ; Seidel, C.* ; Bonsanto, M.M.* ; Bremer, M.* ; Rieken, S.* ; Combs, S.E. ; Herrlinger, U.* ; Seliger, C.* ; Kuntze, H.* ; Mayer-Steinacker, R.* ; Dieing, A.* ; Bartels, C.* ; Schnell, O.* ; Weyerbrock, A.* ; Seidel, S.* ; Grauer, O.* ; Nadji-Ohl, M.* ; Paulsen, F.* ; Weller, M.* ; Wick, W.* ; Hau, P.*

Neurocognitive functioning and health-related quality of life in adult medulloblastoma patients: Long-term outcomes of the NOA-07 study.

J. Neuro-Oncol. 148, 117-130 (2020)
Publ. Version/Full Text Research data DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Background: Combined radiochemotherapy followed by maintenance chemotherapy with cisplatin, lomustine and vincristine within the NOA-07 study resulted in considerable short-term toxicity in adult medulloblastoma patients. Here we investigated the long-term impact of this treatment, focusing on neurocognitive functioning and health-related quality of life (HRQoL). Methods: Neurocognitive functioning and HRQoL scores over time were determined, and differences between the post-treatment and follow-up assessments were calculated up to 18 months for neurocognition and 60 months for HRQoL. Results: 28/30 patients were analyzed. The three preselected HRQoL scales (role, social and cognitive functioning) showed improved scores, to a clinically relevant extent (≥ 10 points), compared to post-treatment levels up to 30 months, but decreased afterwards. Z-scores for verbal working memory were worse during follow-up compared to post-treatment scores and remained impaired during 18 months follow-up (i.e. z-score below − 1 standard deviation). Attention was impaired post-treatment, and remained impaired to a clinically relevant extent during follow-up. Coordination/processing speed and lexical verbal fluency improved compared to post-treatment scores, and remained within the normal range thereafter. Other tests of verbal fluency were stable over time, with z-scores within the normal range. Conclusions: This long-term follow-up study showed that the NOA-07 treatment regimen was not associated with a deterioration in HRQoL in the post-treatment period. Verbal working memory deteriorated, while other neurocognitive domains did not seem to be impacted negatively by the treatment.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Brain Tumor ; Cognition ; Medulloblastoma ; Patient-reported Outcome ; Quality Of Life ; Toxicity; Low-grade Gliomas; Phase-iii; Pediatric Medulloblastoma; Radiotherapy; Impact; Questionnaire; Chemotherapy; Bevacizumab; Validation; Survivors
ISSN (print) / ISBN 0167-594X
e-ISSN 1573-7373
Quellenangaben Volume: 148, Issue: 1, Pages: 117-130 Article Number: , Supplement: ,
Publisher Springer
Publishing Place One New York Plaza, Suite 4600, New York, Ny, United States
Reviewing status Peer reviewed