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Chapouton, P. ; Skupien, P. ; Hesl, B. ; Coolen, M. ; Moore, J.C.* ; Madelaine, R.* ; Kremmer, E. ; Faus-Kessler, T. ; Blader, P.* ; Lawson, N.D.* ; Bally-Cuif, L.

Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells.

J. Neurosci. 30, 7961-7974 (2010)
Verlagsversion DOI
The limited generation of neurons during adulthood is controlled by a balance between quiescence and recruitment of neural stem cells (NSCs). We use here the germinal zone of the zebrafish adult telencephalon to examine how the frequency of NSC divisions is regulated. We show, using several in vivo techniques, that progenitors transit back and forth between the quiescent and dividing state, according to varying levels of Notch activity: Notch induction drives progenitors into quiescence, whereas blocking Notch massively reinitiates NSC division and subsequent commitment toward becoming neurons. Notch activation appears predominantly triggered by newly recruited progenitors onto their neighbors, suggesting an involvement of Notch in a self-limiting mechanism, once neurogenesis is started. These results identify for the first time a lateral inhibition-like mechanism in the context of adult neurogenesis and suggest that the equilibrium between quiescence and neurogenesis in the adult brain is controlled by fluctuations of Notch activity, thereby regulating the amount of adult-born neurons.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Central-nervous-system; Radial glial-cells; Subventricular zone; Self-renewal; Spinal-cord; Oligodendrocyte specification; Primary neurogenesis; Zebrafish retina; HES1 expression; Dentate Gyrus
ISSN (print) / ISBN 0270-6474
e-ISSN 1529-2401
Quellenangaben Band: 30, Heft: 23, Seiten: 7961-7974 Artikelnummer: , Supplement: ,
Verlag Society for Neuroscience
Begutachtungsstatus Peer reviewed