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Anti-inflammatory glucocorticoid action: Genomic insights and emerging concepts.

Curr. Opin. Pharmacol. 53, 35-44 (2020)
Publ. Version/Full Text DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Glucocorticoids (GCs) are widely used immunomodulators. They regulate gene expression by binding and activating the Glucocorticoid Receptor (GR), but underlying transcriptional mechanisms remain enigmatic. This review summarizes recent findings identifyingspecific GR-bound DNA sequences whose configuration may affect transcriptional output. Additional factors affecting GR's anti-inflammatory actions, including different chromatin states such as DNAse hypersensitive regions and histone marks will be discussed, together with the relevant transcriptional co-regulators and promoter/enhancer features. Furthermore, the involvement of non-coding RNAs such as lncRNAs, miRNAs and eRNAs adds another level of regulation to the GR's transcriptional activity. Characterizing and understanding these multiple mechanisms will be crucial for developing more targeted immunomodulatory therapies with reduced adverse effects such as obesity, diabetes and osteoporosis.
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Publication type Article: Journal article
Document type Review
Keywords Dna-binding; Chromatin Accessibility; Receptor Structure; Nuclear Receptors; Kappa-b; Transcription; Repression; Gr; Activation; Mechanisms
ISSN (print) / ISBN 1471-4892
e-ISSN 1471-4973
Quellenangaben Volume: 53, Issue: , Pages: 35-44 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place London
Reviewing status Peer reviewed
Grants Entzuendungsprozesse