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Elhadad, M.A. ; Karavasiloglou, N.* ; Wulaningsih, W.* ; Tsilidis, K.K.* ; Tzoulaki, I.* ; Patel, C.J.* ; Rohrmann, S.*

Metabolites, nutrients, and lifestyle factors in relation to coffee consumption: An environment-wide association study.

Nutrients 12:1470 (2020)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
Coffee consumption has been inversely associated with various diseases; however, the underlying mechanisms are not entirely clear. We used data of 17,752 Third National Health and Nutrition Examination Survey participants to investigate the association of 245 metabolites, nutrients, and lifestyle factors with coffee consumption. We used data from the first phase (n= 8825) to identify factors with a false discovery rate of <5%. We then replicated our results using data from the second phase (n= 8927). Regular coffee consumption was positively associated with active and passive smoking, serum lead and urinary cadmium concentrations, dietary intake of potassium and magnesium, and aspirin intake. In contrast, regular coffee consumption was inversely associated with serum folate and red blood cell folate levels, serum vitamin E and C, and beta-cryptoxanthin concentrations, Healthy Eating Index score, and total serum bilirubin. Most of the aforementioned associations were also observed for caffeinated beverage intake. In our assessment of the association between coffee consumption and selected metabolites, nutrients, and lifestyle factors, we observed that regular coffee and caffeinated beverage consumption was strongly associated with smoking, serum lead levels, and poorer dietary habits.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Coffee Consumption ; Environment Wide Association Study ; Metabolites ; Nutrients ; Lifestyle ; National Health And Nutrition Examination Survey (nhanes); Decaffeinated Coffee; Caffeine Intake; Cancer Risk; Metaanalysis; Tea; Health; Biomarkers; Increases; Mortality; Drinking
ISSN (print) / ISBN 2072-6643
e-ISSN 2072-6643
Zeitschrift Nutrients
Quellenangaben Band: 12, Heft: 5, Seiten: , Artikelnummer: 1470 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed