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Zeigerer, A. ; Kory, N.* ; Krahmer, N.

Hepatic lipid droplet homeostasis and fatty liver disease.

Semin. Cell Dev. Biol. 108, 72-81 (2020)
Postprint DOI Order publishers version
Open Access Green
In cells, lipids are stored in lipid droplets, dynamic organelles that adapt their size, abundance, lipid and protein composition and organelle interactions to metabolic changes. Lipid droplet accumulation in the liver is the hallmark of non-alcoholic fatty liver disease (NAFLD). Due to the prevalence of obesity, the strongest risk factor for steatosis, NAFLD and its associated complications are currently affecting more than 1 billion people worldwide. Here, we review how triglyceride and phospholipid homeostasis are regulated in hepatocytes and how imbalances between lipid storage, degradation and lipoprotein secretion lead to NAFLD. We discuss how organelle interactions are altered in NAFLD and provide insights how NAFLD progression is associated with changes in hepatocellular signaling and organ-crosstalk. Finally, we highlight unsolved questions in hepatic LD and lipoprotein biology and give an outlook on therapeutic options counteracting hepatic lipid accumulation.
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Publication type Article: Journal article
Document type Review
Keywords Lipid Droplet ; Lipid Metabolism ; Nafld ; Nash ; Steatosis ; Vldl; Low-density Lipoprotein; Hormone-sensitive Lipase; Ctp-phosphocholine Cytidylyltransferase; Selective Insulin-resistance; Adipose Triglyceride Lipase; Bile-acid; Endoplasmic-reticulum; Phosphatidylcholine Synthesis; Triacylglycerol Synthesis; Congenital Lipodystrophy
ISSN (print) / ISBN 1084-9521
e-ISSN 1096-3634
Quellenangaben Volume: 108, Issue: , Pages: 72-81 Article Number: , Supplement: ,
Publisher Academic Press
Publishing Place London
Reviewing status Peer reviewed
Grants DZD grant
BMBF
EFSD
DFG
Helmholtz HGF project Aging and Metabolic Programming (AMPro)
EmmyNoether DFG