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Genetic control of non-genetic inheritance in mammals: state-of-the-art and perspectives.

Mamm. Genome 31, 146–156 (2020)
Publ. Version/Full Text DOI
Open Access Gold (Paid Option)
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Thought to be directly and uniquely dependent from genotypes, the ontogeny of individual phenotypes is much more complicated. Individual genetics, environmental exposures, and their interaction are the three main determinants of individual's phenotype. This picture has been further complicated a decade ago when the Lamarckian theory of acquired inheritance has been rekindled with the discovery of epigenetic inheritance, according to which acquired phenotypes can be transmitted through fertilization and affect phenotypes across generations. The results of Genome-Wide Association Studies have also highlighted a big degree of missing heritability in genetics and have provided hints that not only acquired phenotypes, but also individual's genotypes affect phenotypes intergenerationally through indirect genetic effects. Here, we review available examples of indirect genetic effects in mammals, what is known of the underlying molecular mechanisms and their potential impact for our understanding of missing heritability, phenotypic variation. and individual disease risk.
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Publication type Article: Journal article
Document type Review
Keywords Transgenerational Epigenetic Inheritance; Missing Heritability; Quantitative Traits; B-locus; Maize; Rna; Epistasis; Fertilization; Paramutation; Germline
ISSN (print) / ISBN 0938-8990
e-ISSN 1432-1777
Quellenangaben Volume: 31, Issue: , Pages: 146–156 Article Number: , Supplement: ,
Publisher Springer
Publishing Place One New York Plaza, Suite 4600, New York, Ny, United States
Reviewing status Peer reviewed