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Herbert, E.* ; Stewart, M.* ; Hutchison, M.* ; Flenniken, A.M.* ; Qu, D.* ; Nutter, L.M.J.* ; McKerlie, C.* ; Hobson, L.* ; Kick, B.* ; Lyons, B.* ; Wiegand, J.-P.* ; Doty, R.* ; Aguilar-Pimentel, J.A. ; Hrabě de Angelis, M. ; Dickinson, M.* ; Seavitt, J.* ; White, J.K.* ; Scudamore, C.L.* ; Wells, S.*

The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities.

PLoS ONE 15:e0230162 (2020)
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Dislocation in hindlimb tarsals are being observed at a low, but persistent frequency in group-housed adult male mice from C57BL/6N substrains. Clinical signs included a sudden onset of mild to severe unilateral or bilateral tarsal abduction, swelling, abnormal hindlimb morphology and lameness. Contraction of digits and gait abnormalities were noted in multiple cases. Radiographical and histological examination revealed caudal dislocation of the calcaneus and partial dislocation of the calcaneoquartal (calcaneus-tarsal bone IV) joint. The detection, frequency, and cause of this pathology in five large mouse production and phenotyping centres (MRC Harwell, UK; The Jackson Laboratory, USA; The Centre for Phenogenomics, Canada; German Mouse Clinic, Germany; Baylor College of Medicine, USA) are discussed.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 15, Issue: 6, Pages: , Article Number: e0230162 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Reviewing status Peer reviewed