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Multiplexed whole-animal imaging with reversibly switchable optoacoustic proteins.

Sci. Adv. 6:eaaz6293 (2020)
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Open Access Gold
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We introduce two photochromic proteins for cell-specific in vivo optoacoustic (OA) imaging with signal unmixing in the temporal domain. We show highly sensitive, multiplexed visualization of T lymphocytes, bacteria, and tumors in the mouse body and brain. We developed machine learning-based software for commercial imaging systems for temporal unmixed OA imaging, enabling its routine use in life sciences.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Photoacoustic Tomography; Bacteriophytochrome
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Quellenangaben Volume: 6, Issue: 24, Pages: , Article Number: eaaz6293 Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place Washington, DC [u.a.]
Reviewing status Peer reviewed