PuSH - Publikationsserver des Helmholtz Zentrums München

Seq-ing answers: Current data integration approaches to uncover mechanisms of transcriptional regulation.

Comp. Struc. Biotech. J. 18, 1330-1341 (2020)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag

Advancements in the field of next generation sequencing lead to the generation of ever-more data, with the challenge often being how to combine and reconcile results from different OMICs studies such as genome, epigenome and transcriptome. Here we provide an overview of the standard processing pipelines for ChIP-seq and RNA-seq as well as common downstream analyses. We describe popular multi-omics data integration approaches used to identify target genes and co-factors, and we discuss how machine learning techniques may predict transcriptional regulators and gene expression.

Weitere Metriken?
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter ChIP-seq; RNA-seq; NGS; Data integration; Multi-omics; Transcriptional regulation; Differential Expression Analysis; Factor-binding Sites; False Discovery Rate; Gene-expression; Rna-seq; Chromatin States; Sequence; Dna; Quantification; Single
ISSN (print) / ISBN 2001-0370
e-ISSN 2001-0370
Quellenangaben Band: 18, Heft: , Seiten: 1330-1341 Artikelnummer: , Supplement: ,
Verlag Research Network of Computational and Structural Biotechnology (RNCSB)
Verlagsort Radarweg 29, 1043 Nx Amsterdam, Netherlands
Begutachtungsstatus Peer reviewed
Förderungen Helmholtz Association ICEMED