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Insulin und sein Rezeptor – Spezifität durch Kombinatorik?

BioSpektrum 26, 369-371 (2020)
Verlagsversion DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Glucose homeostasis and growth essentially depend on insulin engaging its receptor. Combining biochemistry, structural biology, and molecular dynamics simulations, we demonstrated how insulin binding stabilizes the insulin receptor in a T-shaped conformation with up to four bound ligands: two at receptor site 1 and - for the first time - two at site 2. These findings expand the current models of insulin binding to its receptor and potentially inform new approaches to structure-guided drug design.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0947-0867
e-ISSN 1868-6249
Zeitschrift BioSpektrum
Quellenangaben Band: 26, Heft: 4, Seiten: 369-371 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)