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CREB signalling regulates early survival, neuronal gene expression and morphological development in adult subventricular zone neurogenesis.
Mol. Cell. Neurosci. 46, 79-88 (2011)
eural stem cells in the subventricular zone (SVZ) of the lateral ventricles give rise to new interneurons of the olfactory bulb (OB) throughout life. SVZ/OB neurogenesis is influenced by olfactory network activity, which modulates the survival of new neurons during their integration into the OB network. Previous work suggested that such activity-dependent survival is regulated via the CREB signalling pathway. Curiously, CREB signalling is already active during the early developmental stages of adult SVZ/OB neurogenesis. To investigate the role of cell autonomous CREB signalling during early stages of adult SVZ/OB neurogenesis, we ablated CREB-pathway activity in the SVZ/OB neurogenic lineage using a retroviral strategy. Surprisingly, loss of CREB signalling resulted in increased cell death and loss of expression of the neurogenic transcription factor Pax 6, and of a subset of neuronal proteins in migrating neurons of the RMS. Moreover, post-migratory neurons in the OB displayed impaired dendritic development. These results demonstrate an essential role for CREB signalling in maturation of newborn neurons in the OB and uncover a novel role for CREB signalling in the survival and maintenance of neuronal gene expression during the early stages of SVZ/OB neurogenesis.
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Publication type Article: Journal article
Document type Scientific Article
Keywords CREB; Neuogenesis; Maturation; Survival; Signalling
ISSN (print) / ISBN 1044-7431
Quellenangaben Volume: 46, Issue: 1, Pages: 79-88
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)