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Bornstein, S.R.* ; Malyukov, M.* ; Heller, C. ; Ziegler, C.G.* ; Ruiz-Babot, G.* ; Schedl, A.* ; Ludwig, B. ; Steenblock, C.*

New horizons: Novel adrenal regenerative therapies.

J. Clin. Endocrinol. Metab. 105, 3103-3107 (2020)
Verlagsversion Postprint DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Adrenal insufficiency requires lifelong corticoid replacement therapies. However, current therapies are not able to replace the physiological circadian pattern of the adrenal cortex and are associated with many metabolic, vascular, neuroendocrine, and mental perturbations. Therefore, regenerative and more curative strategies would be desirable. In the current perspective, we describe emerging new regenerative therapies for the treatment of adrenal insufficiency. In particular, we discuss gene therapy and cell replacement strategies. Furthermore, we discuss how adrenal cells might be used as a source for regenerative therapies of nonadrenal neurodegenerative diseases such as Parkinson disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Adrenal ; Stem Cells ; Adrenal Insufficiency ; Cell Replacement ; Gene Therapy ; Regenerative Therapies
ISSN (print) / ISBN 0021-972X
e-ISSN 1945-7197
Quellenangaben Band: 105, Heft: 9, Seiten: 3103-3107 Artikelnummer: , Supplement: ,
Verlag Endocrine Society
Verlagsort Bethesda, Md.
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)
Förderungen Deutsche Forschungsgemeinschaft (DFG, German Research foundation)