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Bheda, P. ; Kirmizis, A.* ; Schneider, R.

The past determines the future: Sugar source history and transcriptional memory.

Curr. Genet. 66, 1029–1035 (2020)
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Open Access Gold (Paid Option)
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Transcriptional reinduction memory is a phenomenon whereby cells "remember" their transcriptional response to a previous stimulus such that subsequent encounters with the same stimulus can result in altered gene expression kinetics. Chromatin structure is thought to play a role in certain transcriptional memory mechanisms, leading to questions as to whether and how memory can be actively maintained and inherited to progeny through cell division. Here we summarize efforts towards dissecting chromatin-based transcriptional memory inheritance ofGALgenes inSaccharomyces cerevisiae. We focus on methods and analyses ofGAL(as well asMALandINO) memory in single cells and discuss the challenges in unraveling the underlying mechanisms in yeast and higher eukaryotes.
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Publication type Article: Journal article
Document type Review
Keywords Transcriptional Memory ; Single-cell ; Inheritance ; Chromatin ; Gal ; Microfluidics ; History-dependent Behavior; Gene Loops
ISSN (print) / ISBN 0172-8083
e-ISSN 1432-0983
Quellenangaben Volume: 66, Issue: , Pages: 1029–1035 Article Number: , Supplement: ,
Publisher Springer
Publishing Place One New York Plaza, Suite 4600, New York, Ny, United States
Reviewing status Peer reviewed