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Correlations of UICC tumor stage and tumor regression on T2-weighted MRI sequences during definitive radiotherapy of cervical cancer.
Tumori 107, 139-144 (2020)
Background: The purpose of this study is to detect a correlation between the preradiation tumor staging and the relative volumetric regression of the primary tumor through external beam radiation therapy (EBRT). Methods: Clinical data of 32 patients with a mean age of 60 +/- 12 years treated with primary radiation therapy (RT) of cervical carcinoma were analyzed. Union Internationale Contre le Cancer (UICC) stages were T1 = 4 patients, T2 = 15 patients, T3 = 8 patients, T4 = 5 patients; N1 = 26 patients, N0 = 6 patients; and M0 = 25 patients, M1 = 7 patients. All patients received pelvic magnetic resonance imaging (MRI) before RT as well as during RT. The cervical primary tumor was delineated as gross tumor volume (ptGTV) in T2-weighted MRI sequences. We compared ptGTV reduction by stage, lymph node status, metastatic status, and grading. Results: Mean ptGTV reduction during RT was 61.4 +/- 28.9%. T1 tumors shrank by 88.2 +/- 13.4%, T2 by 67.6 +/- 28.7%, T3 by 50.8 +/- 23.6%, and T4 by 38.7 +/- 27.2%. The difference in tumor shrinkage was statistically significant between the lower T stages and the higher T stages (p< 0.05). There was no statistical difference in the mean ptGTV before treatment in the group with lymph node metastases (LNM) (54.1 +/- 47.7 cm(3)) as compared to the group without LNM (76.6 +/- 52.2 cm(3)). Nonetheless, ptGTV shrank significantly differently: by 68.9 +/- 25.7% (N1 patients) and by 29.0 +/- 17.7% (N0 patients). No significant differences in ptGTV shrinkage were observed in M0 versus M1 and G2 versus G3 tumors. Conclusion: There is a correlation between mean ptGTV reduction during EBRT and tumor stages. Tumors with higher T stages shrank less under radiation treatment, and the ptGTV of N1 patients responded better than that of N0 patients.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cervical Cancer ; Radiation Therapy ; Staging ; Volumetry ; Mri; Squamous-cell Carcinoma; Radiation-therapy; Concurrent Chemotherapy; Volume; Chemoradiation; Metastasis; Expression; Prediction; Survival; Invasion
ISSN (print) / ISBN 0300-8916
Quellenangaben Band: 107, Heft: 2, Seiten: 139-144
Verlag Sage Publications Ltd
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)