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Riggioni, C.* ; Comberiati, P.* ; Giovannini, M.* ; Agache, I.* ; Akdis, M.* ; Alves-Correia, M.* ; Antó, J.M.* ; Arcolaci, A.* ; Azkur, A.K.* ; Azkur, D.* ; Beken, B.* ; Boccabella, C.* ; Bousquet, J.* ; Breiteneder, H.* ; Carvalho, D.* ; De las Vecillas, L.* ; Diamant, Z.* ; Eguiluz-Gracia, I.* ; Eiwegger, T.* ; Eyerich, S. ; Fokkens, W.* ; Gao, Y.d.* ; Hannachi, F.* ; Johnston, S.L.* ; Jutel, M.* ; Karavelia, A.* ; Klimek, L.* ; Moya, B.* ; Nadeau, K.C.* ; O'Hehir, R.* ; O'Mahony, L.* ; Pfaar, O.* ; Sanak, M.* ; Schwarze, J.* ; Sokolowska, M.* ; Torres, M.J.* ; van de Veen, W.* ; van Zelm, M.C.* ; Wang, D.Y.* ; Zhang, L.* ; Jiménez-Saiz, R.* ; Akdis, C.A.*

A compendium answering 150 questions on COVID-19 and SARS-CoV-2.

Allergy 75, 2503-2541 (2020)
Publ. Version/Full Text Postprint DOI
Open Access Green
In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in similar to 9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.
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Publication type Article: Journal article
Document type Review
Keywords Allergy ; Coronavirus Disease 2019 ; Covid-19 ; Sars-cov-2 ; Severe Acute Respiratory Syndrome-related Coronavirus 2; Acute Respiratory Syndrome; Angiotensin-converting Enzyme; Kawasaki-like Disease; Sars-coronavirus; Longitudinal Profile; Spike Glycoprotein; Immune-responses; Epidemic; Asthma; Azithromycin
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 75, Issue: 10, Pages: 2503-2541 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed