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Pyrina, I.* ; Chung, K.J.* ; Michailidou, Z.* ; Koutsilieris, M.* ; Chavakis, T. ; Chatzigeorgiou, A.*

Fate of adipose progenitor cells in obesity-related chronic inflammation.

Front. Cell Dev. Biol. 8:644 (2020)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
Adipose progenitor cells, or preadipocytes, constitute a small population of immature cells within the adipose tissue. They are a heterogeneous group of cells, in which different subtypes have a varying degree of commitment toward diverse cell fates, contributing to white and beige adipogenesis, fibrosis or maintenance of an immature cell phenotype with proliferation capacity. Mature adipocytes as well as cells of the immune system residing in the adipose tissue can modulate the function and differentiation potential of preadipocytes in a contact- and/or paracrine-dependent manner. In the course of obesity, the accumulation of immune cells within the adipose tissue contributes to the development of a pro-inflammatory microenvironment in the tissue. Under such circumstances, the crosstalk between preadipocytes and immune or parenchymal cells of the adipose tissue may critically regulate the differentiation of preadipocytes into white adipocytes, beige adipocytes, or myofibroblasts, thereby influencing adipose tissue expansion and adipose tissue dysfunction, including downregulation of beige adipogenesis and development of fibrosis. The present review will outline the current knowledge about factors shaping cell fate decisions of adipose progenitor cells in the context of obesity-related inflammation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Preadipocyte ; Adipose Progenitor ; Inflammation ; Adipogenesis ; Beiging ; Obesity ; Fibrosis; Alternatively Activated Macrophages; Adipocyte Differentiation; Tissue Inflammation; Beige Adipocytes; Immune Cells; Adipogenesis; Identification; Alpha; Brown; Interleukin-1-beta
ISSN (print) / ISBN 2296-634X
e-ISSN 2296-634X
Quellenangaben Band: 8, Heft: , Seiten: , Artikelnummer: 644 Supplement: ,
Verlag Frontiers
Verlagsort Lausanne
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)
Förderungen German Research Foundation (DFG)