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Toward targeted prevention: Risk factors for prediabetes defined by impaired fasting glucose, impaired glucose tolerance and increased HbA1c in the population-based KORA study from Germany.

Acta Diabetol. 57, 1481-1491 (2020)
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Open Access Gold (Paid Option)
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Aims To identify socioeconomic, behavioral and clinical factors that are associated with prediabetes according to different prediabetes definition criteria. Methods Analyses use pooled data of the population-based Cooperative Health Research in the Region of Augsburg (KORA) studies (n = 5312 observations aged >= 38 years without diabetes). Prediabetes was defined through either impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or elevated HbA1c according to thresholds of the American Diabetes Association. Explanatory variables were regressed on prediabetes using generalized estimating equations. Results Mean age was 58.4 years; 50% had prediabetes (33% had IFG, 16% IGT, and 26% elevated HbA1c, 10% fulfilled all three criteria). Age, obesity, hypertension, low education, unemployment, statutory health insurance, urban residence and physical inactivity were associated with prediabetes. Male sex was a stronger risk factor for IFG (OR = 2.5; 95%-CI: 2.2-2.9) than for IGT or elevated HbA1c, and being unemployed was a stronger risk factor for IGT (OR = 3.2 95%-CI: 2.6-4.0) than for IFG or elevated HbA1c. Conclusions The overlap of people with IFG, IGT and elevated HbA1c is small, and some factors are associated with only one criterion. Knowledge on sociodemographic and socioeconomic risk factors can be used to effectively target interventions to people at high risk for type 2 diabetes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Prediabetes ; Prevention ; Igt ; Ifg ; Increased Hba1c ; Epidemiology; Life-style Intervention; Type-2 Diabetes-mellitus; Cost-effectiveness; Socioeconomic-status; Prevalence
ISSN (print) / ISBN 0940-5429
e-ISSN 1432-5233
Quellenangaben Volume: 57, Issue: , Pages: 1481-1491 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Milan
Reviewing status Peer reviewed
Grants W.R. Wiley Environmental Molecular Science Laboratory, a national scientific user facility - US Department of Energy's Office of Biological and Environmental Research
United States Department of Energy (DOE)
Munich Center of Health Sciences (MC Health), Ludwig-Maximilians-Universitat (LMU), as part of the LMU innovative
State of Bavaria
Helmholtz Zentrum Munchen (German Research Center for Environmental Health) - German Federal Ministry of Education and Research