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Exploiting common aspects of obesity and cancer cachexia for future therapeutic strategies.

Curr. Opin. Pharmacol. 53, 101-116 (2020)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Obesity and cancer cachexia are diseases at opposite ends of the BMI. However, despite the apparent dichotomy, these pathologies share some common underlying mechanisms that lead to profound metabolic perturbations. Insulin resistance, adipose tissue lipolysis, skeletal muscle atrophy and systemic inflammation are key players in both diseases. Several strategies for pharmacological treatments have been employed in obesity and cancer cachexia but demonstrated only limited effects. Therefore, there is still a need to develop novel, more effective strategies. In this review we summarize existing therapies and discuss potential novel strategies that could arise by bridging common aspects between obesity and cachexia. We discuss the potential role of macrophage manipulation and the modulation of inflammation by targeting Nuclear Receptors (NRs) as potential novel therapeutic strategies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Necrosis-factor-alpha; Adipose-tissue Inflammation; Type-2 Diabetes-mellitus; Cell Lung-cancer; Double-blind; Skeletal-muscle; Tnf-alpha; Insulin Sensitivity; Ppar-gamma; Antibody Treatment
ISSN (print) / ISBN 1471-4892
e-ISSN 1471-4973
Quellenangaben Band: 53, Heft: , Seiten: 101-116 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort London
Begutachtungsstatus Peer reviewed
Förderungen Deutsche Forschungsgemeinschaft DFG
Helmholtz Future Topic Aging and Metabolic Reprogramming (AMPro)