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Käsmann, L.* ; Dietrich, A.* ; Staab-Weijnitz, C.A. ; Manapov, F.* ; Behr, J.* ; Rimner, A.* ; Jeremic, B.* ; Senan, S.* ; De Ruysscher, D.* ; Lauber, K.* ; Belka, C.*

Radiation-induced lung toxicity - cellular and molecular mechanisms of pathogenesis, management, and literature review.

Radiat. Oncol. 15:214 (2020)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-modality care, and treatment-related toxicities, such as radiation-induced pneumonitis and/or lung fibrosis, are important dose limiting factors with direct impact on patient outcomes and quality of life. In this review, we summarize the current understanding of radiation-induced pneumonitis and pulmonary fibrosis, present predictive factors as well as recent diagnostic and therapeutic advances. Novel candidates for molecularly targeted approaches to prevent and/or treat radiation-induced pneumonitis and pulmonary fibrosis are discussed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Obliterans Organizing Pneumonia; Breast-cancer Patients; Hyperfractionated Radiation; Concurrent Chemotherapy; Thoracic Radiotherapy; European-organization; Clinical-features; Tumor Volume; Risk-factors; Stem-cells
ISSN (print) / ISBN 1748-717X
e-ISSN 1748-717X
Zeitschrift Radiation Oncology
Quellenangaben Band: 15, Heft: 1, Seiten: , Artikelnummer: 214 Supplement: ,
Verlag BioMed Central
Verlagsort Campus, 4 Crinan St, London N1 9xw, England
Begutachtungsstatus Peer reviewed
Förderungen NIH/NCI Cancer Center Support Grant
BMBF
DFG
German Cancer Consortium (DKTK)
CPC-M translational funds (German Center for Lung Research (DZL))
Munich Excellence Training Initiative for Physician Scientists (Metiphys)