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Heppt, J.* ; Wittmann, M.T.* ; Schäffner, I.* ; Billmann, C.* ; Zhang, J. ; Vogt Weisenhorn, D.M. ; Prakash, N. ; Wurst, W. ; Taketo, M.M.* ; Lie, D.C.C.*

β-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons.

EMBO J. 39:e104472 (2020)
Verlagsversion Forschungsdaten DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
In adult hippocampal neurogenesis, stem/progenitor cells generate dentate granule neurons that contribute to hippocampal plasticity. The establishment of a morphologically defined dendritic arbor is central to the functional integration of adult-born neurons. We investigated the role of canonical Wnt/β-catenin signaling in dendritogenesis of adult-born neurons. We show that canonical Wnt signaling follows a biphasic pattern, with high activity in stem/progenitor cells, attenuation in immature neurons, and reactivation during maturation, and demonstrate that this activity pattern is required for proper dendrite development. Increasing β-catenin signaling in maturing neurons of young adult mice transiently accelerated dendritic growth, but eventually produced dendritic defects and excessive spine numbers. In middle-aged mice, in which protracted dendrite and spine development were paralleled by lower canonical Wnt signaling activity, enhancement of β-catenin signaling restored dendritic growth and spine formation to levels observed in young adult animals. Our data indicate that precise timing and strength of β-catenin signaling are essential for the correct functional integration of adult-born neurons and suggest Wnt/β-catenin signaling as a pathway to ameliorate deficits in adult neurogenesis during aging.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Adult Neurogenesis ; Aging ; Dendrite ; Hippocampus ; Wnt Signaling
ISSN (print) / ISBN 0261-4189
e-ISSN 1460-2075
Zeitschrift EMBO Journal, The
Quellenangaben Band: 39, Heft: 21, Seiten: , Artikelnummer: e104472 Supplement: ,
Verlag Wiley
Verlagsort Heidelberg, Germany
Begutachtungsstatus Peer reviewed
Förderungen German Research Foundation (DFG)
Bavarian Research Network "ForIPS"
Bavarian Research Network "ForINTER"
University Hospital Erlangen (IZKF grants)