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Targeting ferroptosis: New hope for as-yet-incurable diseases.

Trends Mol. Med. 27, 113-122 (2021)
DOI Order publishers version
Open Access Green: Postprint online available 11/2021
Attaining control over life and death decisions facilitates the identification of new therapeutic strategies for diseases affected by early cell loss or resistance to cell death. In this context, ferroptosis, a prevailing form of non-apoptotic cell death marked by the iron-dependent oxidative destruction of lipid bilayers and metabolic aberrations, has attracted overwhelming interest among basic researchers and clinicians due to its relevance for a number of degenerative diseases, such as neurodegeneration, ischemia/reperfusion injury (IRI), and organ failure, as well as therapy-resistant tumors. As the ferroptotic death pathway offers various druggable nodes, it is anticipated that the preclinical and clinical development of ferroptosis modulators will unleash unprecedented opportunities for the treatment of as-yet-incurable diseases.
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Publication type Article: Journal article
Document type Review
Keywords Cancer ; Ischemia/reperfusion Injury ; Lipid Peroxidation ; Necroinflammation ; Neurodegeneration ; Regulated Necrosis
ISSN (print) / ISBN 1471-4914
e-ISSN 1471-499X
Quellenangaben Volume: 27, Issue: 2, Pages: 113-122 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Reviewing status Peer reviewed
Grants Bavarian Ministry of Economic Affairs, Regional Development and Energy (StMWi)
Else Kroner-Fresenius-Stiftung
Ministry of Science and Higher Education of The Russian Federation
German Federal Ministry of Education and Research (BMBF) VIP+ program NEUROPROTEKT
Deutsche Forschungsgemeinschaft (DFG)