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Mühlenbruch, K.* ; Menzel, J.* ; Dörr, M.* ; Ittermann, T.* ; Meisinger, C. ; Peters, A. ; Kluttig, A.* ; Medenwald, D.* ; Bergmann, M.* ; Boeing, H.* ; Schulze, M.B.* ; Weikert, C.*

Association of familial history of diabetes or myocardial infarction and stroke with risk of cardiovascular diseases in four German cohorts.

Sci. Rep. 10:15373 (2020)
Publ. Version/Full Text Research data DOI
Open Access Gold
Creative Commons Lizenzvertrag
Since family history of diabetes is a very strong risk factor for type 2 diabetes, which is one of the most important risk factors for cardiovascular disease (CVD), it might be also useful to assess the risk for CVD. Therefore, we aimed to investigate the relationship between a familial (parents and siblings) history of diabetes and the risk of incident CVD. Data from four prospective German cohort studies were used: EPIC-Potsdam study (n=26,054), CARLA study (n=1,079), SHIP study (n=3,974), and KORA study (n=15,777). A multivariable-adjusted Cox regression was performed to estimate associations between familial histories of diabetes, myocardial infarction or stroke and the risk of CVD in each cohort; combined hazard ratios (HRMeta) were derived by conducting a meta-analysis. The history of diabetes in first-degree relatives was not related to the development of CVD (HRMeta 0.99; 95% CI 0.88-1.10). Results were similar for the single outcomes myocardial infarction (MI) (HRMeta 1.07; 95% CI 0.92-1.23) and stroke (HRMeta 1.00; 95% CI 0.86-1.16). In contrast, parental history of MI and stroke were associated with an increased CVD risk. Our study indicates that diabetes in the family might not be a relevant risk factor for the incidence of CVD. However, the study confirmed the relationship between a parental history of MI or stroke and the onset of CVD.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Coronary-heart-disease; Parental History; Metaanalysis; Men; Population
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Quellenangaben Volume: 10, Issue: 1, Pages: , Article Number: 15373 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Grants Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) as part of the Collaborative Research Center 598 "Heart failure in the elderly-cellular mechanisms and therapy" at the Medical Faculty of the Martin-LutherUniversity Halle-Wittenberg
Federal Ministry of Science, Germany
European Union
German Cancer Aid
European Community
Ministry for Education, Research, and Cultural Affairs
Ministry for Social Affairs of the Federal State of Mecklenburg-West Pomerania
Helmholtz Zentrum Munchen
German Research Center for Environmental Health - German Federal Ministry of Education, Science, Research and Technology
State of Bavaria
Wilhelm-Roux Programme of the Martin-Luther-University Halle-Wittenberg
Federal Employment Office
Ministry of Education and Cultural Affairs of Saxony-Anhalt
German Federal Ministry of Education and Research (BMBF)