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Khoei, N.S.* ; Anton, G. ; Peters, A. ; Freisling, H.* ; Wagner, K.H.*

The association between serum bilirubin levels and colorectal cancer risk: Results from the prospective cooperative health research in the region of Augsburg (KORA) in Germany.

Antioxidants 9:908 (2020)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
Emerging studies have suggested that bilirubin, particularly unconjugated bilirubin (UCB), has substantial anti-inflammatory and antioxidant properties that protect against oxidative stress-associated diseases such as cancer. Few observational studies have investigated the etiological role of bilirubin in colorectal cancer (CRC) development. In this case-control study, nested in the population-based prospective cohort of the Cooperative Health Research in the Region of Augsburg (KORA) study in south Germany, pre-diagnostic circulating UCB concentrations were measured by high-performance liquid chromatography in 77 CRC cases and their individually matched controls. Multivariable unconditional logistic regression was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) for associations between log-transformed UCB levels (log-UCB), standardized per one-standard-deviation (one-SD) increment, and CRC risk. The models were a priori stratified by sex based on previous evidence. In the fully adjusted models, each one-SD increment in log-UCB was indicative of a positive association with CRC risk (OR, 1.20; 95% CI, 0.52-2.79) among men, and of an inverse association (OR, 0.76; 95% CI, 0.34-1.84) among women (P-heterogeneity = 0.4 for differences between men and women). We found little evidence for sex-specific associations of circulating bilirubin with CRC risk, and further studies are needed to confirm or refute the potential associations.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Bilirubin ; Unconjugated Bilirubin ; Cancer ; Colorectal Cancer ; Antioxidants ; Kora; Oxidative Stress; Bile-pigments; Colon-cancer; Population; Ugt1a1; Antioxidant; Susceptibility; Polymorphisms; Tetrapyrroles; Inflammation
ISSN (print) / ISBN 2076-3921
e-ISSN 2076-3921
Journal Antioxidants
Quellenangaben Volume: 9, Issue: 10, Pages: , Article Number: 908 Supplement: ,
Publisher MDPI
Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland
Reviewing status Peer reviewed
Grants State of Bavaria
Helmholtz Zentrum Munchen, German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
European Commission, BBMRI-LPC (FP7)
Austrian Science Fund (FWF)
French National Cancer Institute (INCa)