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Stazi, M.* ; Negro, S.* ; Megighian, A.* ; D'Este, G.* ; Solimena, M. ; Jockers, R.* ; Lista, F.* ; Montecucco, C.* ; Rigoni, M.*

Melatonin promotes regeneration of injured motor axons via MT1 receptors.

J. Pineal Res. 70:e12695 (2021)
Publ. Version/Full Text DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Melatonin is an ancient multi-tasking molecule produced by the pineal gland and by several extrapineal tissues. A variety of activities has been ascribed to this hormone in different physiological and pathological contexts, but little is known about its role in peripheral neuroregeneration. Here, we have exploited two different types of injury to test the capability of melatonin to stimulate regeneration of motor axons: (a) the acute and reversible presynaptic degeneration induced by the spider neurotoxin alpha-Latrotoxin and (b) the compression/transection of the sciatic nerve. We found that in both cases melatonin administration accelerates the process of nerve repair. This pro-regenerative action is MT1-mediated, and at least in part due to a sustained activation of the ERK1/2 pathway. These findings reveal a receptor-mediated, pro-regenerative action of melatonin in vivo that holds important clinical implications, as it posits melatonin as a safe candidate molecule for the treatment of a number of peripheral neurodegenerative conditions.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Melatonin ; Mt1 And Mt2 Receptors ; Neuromuscular Junction ; Peripheral Nerve Regeneration ; Schwann Cells ; Sciatic Nerve Injury ; Alpha-latrotoxin; Schwann-cells; Molecular Pharmacology; Nerve Injury; Mouse; Pineal; Repair; Mice
ISSN (print) / ISBN 0742-3098
e-ISSN 1600-079X
Quellenangaben Volume: 70, Issue: 1, Pages: , Article Number: e12695 Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)
Grants Consiglio Nazionale delle Ricerche
Italian Ministry of Defence
Universita degli Studi di Padova
Cariparo Foundation