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Breiteneder, H.* ; Peng, Y.Q.* ; Agache, I.* ; Diamant, Z.* ; Eiwegger, T.* ; Fokkens, W.J.* ; Traidl-Hoffmann, C. ; Nadeau, K.* ; O'Hehir, R.E.* ; O'Mahony, L.* ; Pfaar, O.* ; Torres, M.J.* ; Wang, D.Y.* ; Zhang, L.* ; Akdis, C.A.*

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.

Allergy 75, 3039-3068 (2020)
Publ. Version/Full Text DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma, atopic dermatitis, allergic rhinitis, food allergy, urticaria and anaphylaxis. Various biomarkers have been developed by omics technologies, some of which lead to a better classification of distinct phenotypes or endotypes. The introduction of biologicals to clinical practice increases the need for biomarkers for patient selection, prediction of outcomes and monitoring, to allow for an adequate choice of the duration of these costly and long-lasting therapies. Escalating healthcare costs together with questions about the efficacy of the current management of allergic diseases require further development of a biomarker-driven approach. Here, we review biomarkers in diagnosis and treatment of asthma, atopic dermatitis, allergic rhinitis, viral infections, chronic rhinosinusitis, food allergy, drug hypersensitivity and allergen immunotherapy with a special emphasis on specific IgE, the microbiome and the epithelial barrier. In addition, EAACI guidelines on biologicals are discussed within the perspective of biomarkers.
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Publication type Article: Journal article
Document type Review
Keywords Allergen Immunotherapy ; Allergic Rhinitis ; Asthma Phenotypes And Endotypes ; Biomarkers ; Food Allergy; Basophil Activation Test; Ara H 2; Innate Lymphoid-cells; Type-2 Immune-response; Nasal Epithelial-cells; Chronic Rhinosinusitis; Peanut Allergy; Oral Immunotherapy; Eaaci Guidelines; Sublingual Immunotherapy
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 75, Issue: 12, Pages: 3039-3068 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute of Environmental Medicine (IEM)