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Hinterseer, M.* ; Thomsen, M.B.* ; Beckmann, B.M.* ; Pfeufer, A. ; Schimpf, R.* ; Wichmann, H.-E. ; Steinbeck, G.* ; Vos, M.A.* ; Kääb, S.*

Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: A case control pilot study.

Eur. Heart J. 29, 185-190 (2008)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Torsades de pointes arrhythmias (TdP) occur by definition in the setting of prolonged QT intervals. Animal models of drug induced Long-QT syndrome (dLQTS) have shown higher predictive value for proarrhythmia with beat-to-beat variability of repolarization duration (BVR) when compared with QT intervals. Here, we evaluate variability of QT intervals in patients with a history of drug-induced long QT syndrome (dLQTS) and TdP in absence of a mutation in any of the major LQTS genes. METHODS AND RESULTS: Twenty patients with documented TdP under drugs with QT-prolonging potential were compared with 20 matched control individuals. An observer blinded to diagnosis manually measured lead-II, RR, and QT intervals from 30 consecutive beats. BVR was determined from Poincaré plots of QT intervals as short-term variability (STV(QT) = Sigma
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Publication type Article: Journal article
Document type Scientific Article
Keywords Torsades de Pointes; Drug induced Long QT Syndrome; Beat-to-beat Variability of repolarization; Proarrhythmia
ISSN (print) / ISBN 0195-668X
e-ISSN 1522-9645
Quellenangaben Volume: 29, Issue: 2, Pages: 185-190 Article Number: , Supplement: ,
Publisher Oxford University Press
Reviewing status Peer reviewed