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Kokot, H.* ; Kokot, B.* ; Sebastijanović, A.* ; Voss, C. ; Podlipec, R.* ; Zawilska, P.* ; Berthing, T.* ; Ballester-Lopez, C. ; Danielsen, P.H.* ; Contini, C.* ; Ivanov, M.* ; Krišelj, A.* ; Čotar, P.* ; Zhou, Q. ; Ponti, J.* ; Zhernovkov, V.* ; Schneemilch, M.* ; Doumandji, Z.* ; Pušnik, M.* ; Umek, P.* ; Pajk, S.* ; Joubert, O.* ; Schmid, O. ; Urbančič, I.* ; Irmler, M. ; Beckers, J. ; Lobaskin, V.* ; Halappanavar, S.* ; Quirke, N.* ; Lyubartsev, A.P.* ; Vogel, U.* ; Koklič, T.* ; Stöger, T. ; Štrancar, J.*

Prediction of chronic inflammation for inhaled particles: The impact of material cycling and quarantining in the lung epithelium.

Adv. Mater., accepted (2020)
Publ. Version/Full Text DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
On a daily basis, people are exposed to a multitude of health-hazardous airborne particulate matter with notable deposition in the fragile alveolar region of the lungs. Hence, there is a great need for identification and prediction of material-associated diseases, currently hindered due to the lack of in-depth understanding of causal relationships, in particular between acute exposures and chronic symptoms. By applying advanced microscopies and omics to in vitro and in vivo systems, together with in silico molecular modeling, it is determined herein that the long-lasting response to a single exposure can originate from the interplay between the newly discovered nanomaterial quarantining and nanomaterial cycling between different lung cell types. This new insight finally allows prediction of the spectrum of lung inflammation associated with materials of interest using only in vitro measurements and in silico modeling, potentially relating outcomes to material properties for a large number of materials, and thus boosting safe-by-design-based material development. Because of its profound implications for animal-free predictive toxicology, this work paves the way to a more efficient and hazard-free introduction of numerous new advanced materials into our lives.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Advanced Microscopies ; Adverse Outcome Pathways ; Disease Prediction ; Material Safety And Health Hazards ; Mode Of Action; Molecular-dynamics; Chemical Safety; Nanomaterials; Responses; Nanotoxicology; Nanoparticles; Exposure; Matter; Hazard; Actin
ISSN (print) / ISBN 0935-9648
e-ISSN 1521-4095
Publisher Wiley
Publishing Place Weinheim
Reviewing status
Grants Crossing borders and scales - an interdisciplinary approach (CROSSING project)
Science Foundation Ireland
China Scholarship Council (CSC fellowship)
Genomics Research and Development Initiative and Chemicals Management Plan of Health Canada
Helmholtz Alliance "Aging and Metabolic Programming, AMPro"
Slovenian Research Agency Young Researcher Program
Slovenian Research Agency
EU Horizon 2020 Grant