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Kanellakis, N.I.* ; Asciak, R.* ; Hamid, M.A.* ; Yao, X.* ; McCole, M.* ; McGowan, S.* ; Seraia, E.* ; Hatch, S.* ; Hallifax, R.J.* ; Mercer, R.M.* ; Bedawi, E.O.* ; Jones, S.* ; Verrill, C.* ; Dobson, M.* ; George, V.* ; Stathopoulos, G.T. ; Peng, Y.* ; Ebner, D.* ; Dong, T.* ; Rahman, N.M.* ; Psallidas, I.*

Patient-derived malignant pleural mesothelioma cell cultures: A tool to advance biomarker-driven treatments.

Thorax 75, 1004-1008 (2020)
Verlagsversion Forschungsdaten DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Malignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM. Patient-derived MPM cell cultures (n=16) exhibited stemness features and reflected intratumour and interpatient heterogeneity. A subset of the cells were subjected to high-throughput drug screening and coculture assays with cancer-specific cytotoxic T cells and showed diverse responses. Some of the biphasic MPM cells were capable of processing and presenting the neoantigen SSX-2 endogenously. In conclusion, patient-derived MPM cell cultures are a promising and faithful ex vivo model of MPM.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Mesothelioma ; Pleural Disease; Establishment; Lines
ISSN (print) / ISBN 0040-6376
e-ISSN 1468-3296
Zeitschrift Thorax
Quellenangaben Band: 75, Heft: 11, Seiten: 1004-1008 Artikelnummer: , Supplement: ,
Verlag BMJ Publishing Group
Verlagsort British Med Assoc House, Tavistock Square, London Wc1h 9jr, England
Begutachtungsstatus Peer reviewed
Förderungen Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (CIFMS)
Oxfordshire Health Services Research Committee (OHSRC) Research Grant
Medical Research Council, UK
National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC) grant
University of Oxford's Medical Sciences Division
NIHR Thames Valley and South Midlands Clinical Research Network
Oxford Cancer Centre (CRUK)
NIHR Oxford Biomedical Research Centre (Molecular Diagnostics theme)