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Wu, F.* ; Cheng, Y.* ; Wu, L.* ; Zhang, W.* ; Zheng, W.* ; Wang, Q. ; Cao, H.* ; Pan, X.* ; Tang, W.*

Emerging landscapes of tumor immunity and metabolism.

Front. Oncol. 10:575037 (2020)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
The metabolic reprogramming of cancer tissue has higher metabolic activity than surrounding tissues. At the same time, the local infiltration of immunosuppressive cells is also significantly increased, resulting in a significant decrease in tumor immunity. During the progression of cancer cells, immunosuppressive tumor microenvironment is formed around the tumor due to their metabolic reprogramming. In addition, it is the changes in metabolic patterns that make tumor cells resistant to certain drugs, impeding cancer treatment. This article reviews the mechanisms of immune escape caused by metabolic reprogramming, and aims to provide new ideas for clinical tumor immunotherapy combined with metabolic intervention for tumor treatment.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Cancer ; Metabolism ; Immunity ; Reprogram ; Drug Resistance; T-cell Metabolism; Molecular Pathways; Antitumor Immunity; Glutamine Uptake; Cancer; Memory; Acid; Resistance; Kinase; Expression
ISSN (print) / ISBN 2234-943X
e-ISSN 2234-943X
Zeitschrift Frontiers in Oncology
Quellenangaben Band: 10, Heft: , Seiten: , Artikelnummer: 575037 Supplement: ,
Verlag Frontiers
Verlagsort Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Begutachtungsstatus Peer reviewed
Förderungen Jiangsu Natural Science Foundation